cis-dichloroamminecyclo hexaneamineplatinum(II)

cis-Dichloroamminecyclohexaneamineplatinum(II) is a platinum-based antitumor compound, often referred to as JM118. It is a second-generation platinum drug that is of significant interest in anticancer research, particularly for overcoming cisplatin resistance. Basic InformationCommon name: JM118CAS number: 99038-38-7Molecular formula: C6H16Cl2N2PtMolecular weight: approx. 382.2 g/molStructure identifiers:SMILES: C1CCC(CC1)N.N.[Cl-].[Cl-].[Pt+2]InChIKey: OSALTHMLNADUIV-UHFFFAOYSA-L Structure and PropertiesCentral atom: platinum(II) ion (Pt2+)Coordination geometry: square planar (typical for Pt(II) complexes)Ligands: two chloride ions (Cl-), one ammonia molecule (NH3), and one cyclohexylamine molecule coordinated to the platinum centreStereochemistry: the two chloride ions are in a cis relationship Main UsesAnticancer drug research: as a cisplatin analogue, JM118 is widely studied for its DNA interactions and antitumour activity.Overcoming cisplatin resistance: studies show that JM118 a…

Pharmaceutical Intermediates Pharmaceutical APIs